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Once expressed, EGR-1 binds to the DNA of other genes and controls their transcription, initiating a cascade of events leading to tissue repair

The extraction was done in a buffer [1.0 mm ethylenediaminetetraacetic acid (EDTA), 100 mM TrisHCl (pH 7.3), 100 mM -mercaptoethanol, 1.0 mM phenyl methyl sulfonyl fluoride, 0.1 mM protease inhibitor cocktail, 2% glycerol, 25 mM MgCl 2 , 10 mM dipotassium hydrogen phosphate (K 2 HPO 4 )] and centrifuged at 12,000 g for 15 min, 4 C

Pak et al., 2018)

Compared with large biologic medicines such as monoclonal antibodies, they are often smaller and sometimes easier to synthesize or modify