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and Hruby, V.J., Life Sci (1982) 31:189-199 (-CH -S-)' Peptide mimetics may have significant advantages over polypeptide embodiments, including, for example: more economical production, greater chemical stability, enhanced pharmacological properties (half-life, absorption, potency, efficacy, etc.), altered specificity (e.g., a broad-spectrum of biological activities), reduced antigenicity, and others

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An orphan receptor, GPR17, binds cysLTs and may negatively regulate the function of cysLT 1 , but its physiologic role remains ill defined