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10.1085/jgp.36.1.39 57 HibiK.AmikuraK.SugiuraN.MasudaK.OhnoS.YokogawaT.et al (2020)

3.2 HPA-axis dysregulation Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis constitutes a significant characteristic of major depressive disorder

Also, avoid using melatonin with alcohol (for adults) or with other sedative supplements (like high-dose valerian or kava) unless guided by a doctor, to prevent any excessive combined sedation