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Resveratrol at a lower dose (2.5 mg/kg/day) for 5 days (followed by 22 days in the dark) also showed positive outcomes in terms of insulin tolerance and cell signaling in the liver [31]

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Di Domenico F, Tramutola A, Foppoli C, Head E, Perluigi M, Butterfield DA (2018) mTOR in Down syndrome: role in A and tau neuropathology and transition to Alzheimer disease-like dementia