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1 The British Society for Haematology does not recommend retesting vitamin B 12 levels after treatment has been initiated, and no guidelines address the optimal interval for screening high-risk patients

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However, in the presence of constant pro-angiogenic signaling in the tumor, the newly formed vascular networks may fail to mature and prune, the division into arterioles, capillaries and venules may be lacking, vessel caliber size can be markedly heterogeneous and blood flow through the poorly organized and malformed vessels can be chaotic [82, 83]

Protocol optimization based on response