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The structure of EPI-743 is based on vitamin E and its proposed mechanisms-of-action includes augmenting glutathione synthesis and acting at the mitochondrial level to regulate electron transport

In animal studies, LC was found to increase the levels of circulating insulin-like growth factor-1 (IGF-1), which consequently led to the activation of protein kinase B (Akt) and the mammalian target of rapamycin (mTOR) []

The diversity in mRNA expression levels might arise due to a myriad of factors, potentially linked to cellular context, tissue specificity, and even cancer types