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Mechanistically, these effects appeared to be mediated through mitochondrial uncoupling, AMPK activation, modulation of mTOR and PPAR signaling, improved mitochondrial bioenergetics, antioxidant defense and global metabolic reprogramming (Fig

Numerous clinical treatment drugs for HCC, including bevacizumab, sorafenib, lenvatinib, regorafenib, and cisplatin, increase ROS levels, activating the intrinsic apoptotic pathway [243,244,245,246,247]

Replace 100 l with sample or 100 l of a series of standards treated with 2-vinylpyridine, where appropriate, which are prepared as described in Step 2B