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In the lung tissue of patients with mild to moderate COPD, there is a significant increase in CD8+ T cell subsets, particularly KLRG1+TIGIT+CX3CR1+ TEMRA (effector memory CD45RA+ T cells) and DNAM-1+CCR5+ TRM cells

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Subsequent work further established that the antifolate compounds LTX and PTX inhibit SHMT2, with LTX identified as the most potent SHMT2 inhibitor reported to date, followed by PTX [161]