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"We believe maintaining the glutathione-to-iron ratio is very important, because if you have too little glutathione, then iron becomes very reactive, and if you have too much glutathione, the iron will not be usable." Their experiments determined that SLC25A39 carries a unique iron signature on its surface as part of the glutathione sensing mechanism

Normal (non-cancer) rectal tissue biopsies were obtained during colonoscopy from consenting patients who did not have a cancer diagnosis

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