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TGF-: the sword, the wand, and the shield of FOXP3 + regulatory T cells

The GPCR family is exceptionally important clinically, as demonstrated by the fact that 35% of FDA-approved drugs target GPCRs or elements of their down-stream signaling pathways

Bowcock AM

Some small human trials mostly in PBC and insulin resistance show encouraging results, while larger, more definitive studies are still missing.4 6 In other areas, like amyotrophic lateral sclerosis (ALS) and neuroprotection, the story is even less clear: despite promising preclinical data, a recent Phase 3 ALS trial failed to confirm meaningful benefit.23 24 To help make sense of this, weve summarized the potential benefits of TUDCA in the chart below