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Proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy may be modulated by the interconversion of glutamate, ornithine, and proline, among which proline is the key amino acid (98)

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Nonpharmacologic treatment options with published evidence of efficacy in patients with CIPN include chemotherapy dose reduction, discontinuation of the offending chemotherapeutic agent(s), acupuncture, avoiding cold temperatures/maintaining warmth, physical activity, and massaging affected areas ( TABLE 3 )