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D1 dopaminergic control of G protein-dependent inward rectifier K + (GIRK)-like channel current in pyramidal neurons of the medial prefrontal cortex

Interestingly, both in vivo and in vitro studies have shown that the accumulation of -syn in the mitochondria of human DA neurons leads to decreased complex I activity, increased production of ROS, reduced substrate-specific respiration, and increased mitophagy [86, 87]

While exogenous antioxidants may attenuate training adaptations, there is no literature to suggest that increasing endogenous antioxidants has this effect

FIGURE 5 Importantly, the influence of an environmental stressor like elevated temperature (or hypoxia, diminished food resources, competition, etc