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Besides, GPX4 is mainly involved in the redox reaction of ferroptosis (Ursini et al., 1982), reducing LPO and maintaining cellular redox homeostasia

The combined PQ and FA treatment was performed in the same way as the NAC/FA treatment, with the exception that PQ was added at the same time as FA (2 mmol L 1 ) and incubated together for a total of 5 h

These transcriptional changes indicate enhanced apoptosis and reduced cell proliferation, consistent with the effects of severe ER stress

While most studies have focused on SLC7A11-mediated cystine import, this study suggests that SLC7A11-mediated glutamate export can cross-talk with and modulate tumor immune systems, which in turn influence tumor growth and response to cancer therapies