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67 Non-proliferative astrogliosis typically occurs in neural tissue that is responding to a pathology but is not overtly damaged and retains its basic tissue architecture, for example (i) during diffuse neuroinflammation caused by peripheral exposure to microbial antigens such as lipopolysaccharide (LPS), 68,69 (ii) in tissue regions that are at a distance from focal lesions (diaschisis) caused by stroke, trauma or autoimmune attack, 8,70 or (iii) in tissue undergoing neurodegenerative changes

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In addition to a kinetic response to changes in Cys concentration, the catalytic turnover of Cys by CDO leads to conversion of CDO to its mature (Cys-Tyr cofactor-containing) form that has a markedly increased catalytic efficiency (k cat /K m ) and longer catalytic half-life, as discussed earlier

Research confirms that probiotics frequently demonstrate a superior capacity for epithelial adhesion compared to pathogens (193)