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The therapy is generally recommended to fit patients in the second line, especially to ease symptoms or as a bridge to targeted treatments within or outside of clinical trials

The enhanced autophagy in drug-resistant cells is mainly due to the destruction of mitochondrial function caused by tamoxifen, and drug-resistant cells meet their energy demand through autophagy

Alpha-1 antitrypsin deficiency affects approximately 1 in 2,0006,000 individuals globally, with an estimated 3.4 million people harboring severe deficiency alleles and over 116 million carriers worldwide [20, 21]

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