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Hypomethylation at this site was associated with an upregulation in BACE1 gene products and corresponded to an increase in amyloid plaque load, neurofibrillary tangle density, and a higher severity of cognitive symptoms

Insomnia, the most common sleep disorder, is associated with a 24hour increase of ACTH and cortisol secretion, consistent with a disorder of central nervous system hyperarousal

Release of Ca2+ from the endoplasmic reticulum and its subsequent influx into mitochondria trigger celastrol-induced paraptosis in cancer cells

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