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Most experienced users recommend starting conservatively and titrating upward based on individual response

10.1093/oxfordjournals.pcp.a029440 92 MullenR

Because telomeres contain not only G4 DNA formed by telomeric DNA, but also G4 RNA formed by TERRA transcribed from telomeres, the competitive binding of transcribed TERRA to EWS might suppress the activity of TERRA transcription by EWS