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In response to oxidative stress, mitochondrial DNA (mtDNA) is highly susceptible to damage due to its proximity to the ETC, lack of protective histones, and inefficient DNA repair mechanisms

The spinal antinociceptive actions of morphine metabolites morphine-6-glucuronide and normorphine in the rat

This is exemplified by variable responsiveness to therapeutics such as those targeting IL-23/IL-17 signalling, and other consistently observed differences in clinical course including progression and severity both within and between SpAs subtypes

Like why post-surgical protocols favor lower dosing despite similar tissue repair mechanisms as acute injury protocols