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It has been demonstrated that ROS-based therapy can trigger dendritic cells (DCs) maturation and strengthen tumor immunity by inducing tumor ICD, illustrated by the release of damage-associated molecular patterns (DAMPs), such as calreticulin (CRT), intracellular high-mobility group protein B1 (HMGB1) and cell-surface heat-shock proteins 70 kDa (HSP70) 42,43,44

88 Similarly, IL-13 the T-helper type 2 cytokine and key effector of ulcerative colitis also affects intestinal epithelial cell TJ function as well as apoptosis, 89 and was recently shown to regulate claudin-2 transcription in a signal transducers and activators of transcription-dependent manner

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