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The disruption of this signaling pathway, especially due to mutations such as KRASG12D (Hill et al., 2010[50]

doi: 10.1016/j.abd.2020.09.004

Ethacraplatin a dual-threat platinum (IV) prodrug is a cisplatin molecule coordinated to two ethacrynic acid ligands which is able to inhibit irreversibly GSTP1-1 enzymatic activity being reduced and cleaved as a consequence of binding (Fig