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Unlike most peptides, MOTS-c originates in the mitochondria, the energy-producing centers of cells, and works by improving metabolic efficiency and stress resilience

We recently demonstrated that in HEK293 cells over-expressing IGF-1 isoforms the proIGF-1s are the main forms produced intracellularly, and for proIGF-1Ea both unglycosylated (~12 kDa) and glycosylated (~17 kDa) forms were detected 7

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