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doi: 10.3389/fimmu.2025.1713426 Received 26 September 2025 Revised 13 December 2025 Accepted 19 December 2025 Published 24 March 2026 Volume 16 - 2025 Edited by Daniel P

J Cell Biol (2018) 217:191528

Enzymatic degradation by proteases and chemical instability can limit therapeutic effectiveness and require specialized storage and handling procedures