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Ana Sierra: Uh, pelvic vein specialist

doi: 10.1016/j.bpj.2017.08.050, 145

if you are pregnant

Thus, while the estimation of the amount of a loading dose may be quite correct, the rate of administration can sometimes be crucial in preventing excessive drug concentrations, and slow administration of an intravenous drug (over minutes rather than seconds) is almost always prudent practice