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Isolation, identification, and structure-activity relationship of novel ACE inhibitory peptides from earthworm protein in vitro gastrointestinal digestion product

Kornblau SM, Gandhi V, Andreeff HM, Beran M, Kantarjian HM, Koller CA, O'Brien S, Plunkett W, Estey E

Direct injection onto the lyophilised powder at high velocity creates localised turbulence that disrupts hydrogen bonds holding the protein in its biologically active conformation

The established in vitro bioassay might be a useful tool in screening for potential inducers of oxidative stress, both regarding toxicity of pure compounds and for analysis of environmental samples, e.g