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While interferon- (IFN-)-associated Th1 and interleukin-17 (IL-17)-associated Th17 cells are considered to lead to disease progression and worsening of symptoms, IL-4-associated Th2 and transforming growth factor- (TGF-)-associated Treg have been indicated to associate with inflammation reduction and improvement of symptoms in MS patients [69]

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Furthermore, gut microbiota dysbiosis and altered gut microbial metabolite synthesis, such as short-chain fatty acids (SCFAs), can impact neuronal signaling and cognitive processes

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