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Importantly, co-treatment with PWE effectively normalized the expression of all three markers, restoring PECAM-1, NRF2, and HO-1 protein levels to values comparable to controls (Figures 6A,B)

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Apparently, after sensitization, T-cells are less capable of recirculating through the lymphoid organs, but gain ability to migrate into the peripheral tissues

Endocr Rev 39(5):760802 Zhang H et al (2021) PPARalpha agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway