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Thus, although there is no direct contact between NS5B and D1467, the D1467G mutation may alter the NS3hNS5B interaction by weakening long-range electrostatic interactions

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 Degron and the Redox-insensitive Neh6 Degron

Additionally, butyrate regulates gut immune cell function by inhibiting histone deacetylase (HDAC) activity, promoting the differentiation of Treg, and suppressing the release of pro-inflammatory cytokines such as IL-6 and TNF-, thereby alleviating intestinal inflammation [439, 440]

It helps replenish fluids lost during sleep, supports metabolism, and prepares the digestive tract for food intake