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The condition has a significant impact on the mental well-being of patients and adversely affects their overall quality of life (128, 129)

The molecule is small, cheap to synthesise, and would be difficult to defend commercially

10.1016/j.isci.2020.101077 iScience 71 HeimM.FrankO.KampmannG.SochockyN.PennimpedeT.FuchsP.et al (2004)

However, in some assays that use target cells defective for Nef and/or Vpu expression, CD4 expressed by these cells is not downregulated and can capture shed gp120