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While tirzepatide does not directly target reproductive hormones, the significant weight loss and metabolic changes it produces can influence the hypothalamic-pituitary-ovarian axis that regulates menstruation

In the treatment of breast cancer, anti-estrogen tamoxifen, the drug most often used for the long-term treatment of early breast cancer, can induce apoptosis in many cells, and this effect may be mediated by ROS generation in the mitochondria of breast cancer cells [71]