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Genes, Brain Behav (2016) 16(1):86100

Translational limitations Despite substantial preclinical evidence supporting the neuroprotective and procognitive GlyT1 inhibition neurobiological effects, clinical translation has encountered considerable limitations

Development of insulin resistance in mice lacking pgc-1 in adipose tissues

Animal studies show LR3 IGF-1 increases body weight gain, nitrogen retention, and food conversion efficiency (Tomas et al., 1993) and suppresses muscle protein degradation pathways within an hour (Sacheck et al., 2004)