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Rating: 4.1314 (12 reviews)

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it can inactivate the generation of pro-inflammatory mediators in microglia by affecting the NF-B, p38/MAPK and Nrf2/ARE-dependent signaling pathways, thus inhibiting activation of the immune response following cerebral ischemia (117)

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Pinto, G., Shtaif, B., Phillip, M

Cocaine binds with high affinity to the norepinephrine transporter (NET) on the presynaptic nerve terminal (Kd 0.3 M), acting as a transmembrane physical plug that inhibits reuptake of norepinephrine