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Variation in Cyp2a6 activity and personalized medicine

The Journal of Immunology

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The central role of CCL2 and CCL7, and thus MoAM, in lung inflammation and pathology is corroborated by a strongly impaired recruitment of monocytes into the lung and protection from pulmonary emphysema upon inhibition of the CCR2/CCL2 axis ( We have shown that recruited neutrophils comprise functionally distinct subsets including a rare subset (N5) characterized by an interferon response signature, which has previously also been observed in lung cancer tissue of humans and mice ( Cxcl10 , which is increased in sputum of COPD patients and smokers and known to induce emphysema associated MMP-12 ( + T-cells, are increased in COPD patients and CD8 + T-cells were shown to be involved in the development of CS-induced emphysema ( Il1f9, Il1b) ( Tnf , suggest that they are a second important regulator of smoke-induced pulmonary inflammation and tissue damage