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Concomitant inhalation of mainstream cigarette smoke with aerosolized harmless antigenwithout prior sensitizationelicited features of allergic inflammation in mice, characterized by peribronchial eosinophilic infiltrates, goblet cell hyperplasia, enhanced levels of allergen-specific serum IgE, and IL-5 production in draining lymph nodes (LNs)

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The diagnosis: pleural effusion, a buildup of fluid in the tissues around the lung, and empyema, an accumulation of pus in the same area that is often caused by pneumonia