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Mice with inactivation of the urokinase plasminogen activator receptor (uPAR) gene, a key component of the HGF activation (Blasi, 1993), show diminished levels of HGF in cortical interneurons beginning at E16.5, indirectly suggesting that HGF has motogenic effects also on cortical interneuron precursors (Powell et al., 2001)

Following up on their discovery, this same group of researchers tested the effects of 9-me-BC in vivo, by administering the drug intraperitoneally to rats for either 5 or 10 days, and testing their performance in the well-known spatial learning task, the radial arm maze