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Autophagy, a cellular survival mechanism under stress conditions, can lead to cell death if excessive

Key unresolved questionsincluding the exact temporal sequence and causal relationship between NTFs signaling dysfunction and mitochondrial impairment in human PD, the existence of an irreversible threshold beyond which intervention is ineffective, and the universal applicability of preclinical findings to sporadic PDmust be addressed through rigorous, human-relevant research