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In turn, miR-206 agonist (agomiR-206-3p) significantly weakened the anti-dementia effects of donepezil

To assess the amphetamine exposure-effect relationship, the changes in pharmacodynamic effect after lisdexamfetamine and D-amphetamine administration for each time point were plotted against the respective plasma concentrations of amphetamine (hysteresis plots)

These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients