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It acts as a dual agonist at amylin receptors (AMY1R, AMY2R, AMY3R, formed by calcitonin receptor heterodimerized with RAMP1-3) and calcitonin receptors, with structural modifications (e.g., N-terminal fatty acid acylation, proline substitutions) preventing fibril formation, enhancing stability, and enabling once-weekly dosing via albumin binding for prolonged circulation

Cengiz, M

The starting conformations were obtained by manually binding GS(H) to a snapshot of the MD simulation of TRaQ-G and the crystal structure of MeTRaQ-G, respectively

Within experimental models, the blend is commonly investigated for peptide-mediated signalling dynamics and molecular interaction mechanisms