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Nitric oxide and other ROS inhibit mitochondrial 2-oxoglutarate dehydrogenase giving rise to increased levels of glutamate, which eventually leads to glutamate excitotoxicity and cell death (Weidinger et al., 2017)

Cardiovascular effects at peak: Peak MDMA plasma levels drive the greatest cardiovascular strain, including heart rate increases of 20 to 30 beats per minute, systolic blood pressure elevation of 20 to 30 mmHg, and core body temperature rises that can exceed 40C (104F) in hot, crowded environments

Cells were exposed to 0-, 50-, or 100-mM ethanol for 48 h, and the medium was changed every 24 h

Es kann auch als Reservespeicher fr die Aminosure L-Cystein dienen