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Complex-I inhibition is associated with the excessive generation of ROS

Aliment Pharmacol Ther 40(5):565 Lichtwark IT, Newnham ED, Robinson SR et al (2014) Cognitive impairment in coeliac disease improves on a gluten-free diet and correlates with histological and serological indices of disease severity

As previously discussed, toxic blood components interact with TLR-4, inducing the production of various proinflammatory cytokines (e.g., IL-1, IL-6, IL-10, TNF) via the NFB pathway, involving both resident CNS cells and infiltrating leukocytes