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[52] As many of the downstream transducer and effector molecules of GPCRs (including those involved in negative feedback pathways) are also targeted to lipid rafts, this has the effect of facilitating rapid receptor signaling

(9) Elena M Khvatova, Victor N Samartzev, Pavel P Zagoskin, Igor A Prudchenko, and Inessa I Mikhaleva (2003) Delta sleep inducing peptide (DSIP): effect on respiration activity in rat brain mitochondria and stress protective potency under experimental hypoxia Peptides, 2003 Feb, Volume 24 (Issue 2), Pages 307-11

2022) which requires the deactivation of tumour suppressor genes such as P53, RB and p16 (Dimri et al 2005) and/or activation of oncogenes